📝 Selected Publications

An energy costly architecture of neuromodulators for human brain evolution and cognition

Gabriel Castrillon, Samira Epp, Antonia Bose, Laura Fraticelli, Andre Hechler, Roman Belenya, Andreas Ranft, Igor Yakushev, Lukas Utz, Lalith Sundar, Josef P Rauschecker, Christine Preibisch, Katarzyna Kurcyus, Valentin Riedl

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I audited where all the sugar is spent in the 🧠, generating a map of the energetic costs, interpreted from evolutive, cytoarchitectural, molecular, and cognitive points of view.

BOLD signal changes can oppose oxygen metabolism across the human cortex

Samira Epp, Gabriel Castrillon, Beijia Yuan, Jessica Andrews-Hanna, Christine Preibisch, Valentin Riedl

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Samira showed that roughly 40% of robust BOLD voxels flip their oxygen‑metabolism response, exposing two distinct hemodynamic modes.

Simultaneous quantification of oxygen and glucose consumption during visual stimulation in the human cortex

Antonia Bose & Samira Epp, Roman Belenya, Katarzyna Kurcyus, Eric Ceballos Dominguez, Andreas Ranft, Eliana Salas Villa, Moritz Bursche, Christine Preibisch, Gabriel Castrillon & Valentin Riedl

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We simultaneously measured CMRO2 and CMRglc for the first time, showing an increase in glucose metabolism without a corresponding rise in oxygen consumption, which suggests an enhanced glycolytic metabolism during brain activity.

The control costs of human brain dynamics

Eric Ceballos Dominguez, Andrea I. Luppi, Gabriel Castrillon, Manish Saggar, Bratislav Misic, Valentin Riedl

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Eric showed that the brain balances functional efficiency and energy conservation by minimizing costly transitions between different activity states using network control theory.